Scientists believe that they may have found a potential life-prolonging technique as they are studying a reversible aging cell group.
Humanity has been constantly battling growing old and aging. Be it through creams or treatments, people seem to be more and more intent on staying young.
Now, a group of researchers states that they may have actually discovered a solution. If proven efficient, their technique could ensure both a younger look and life.
Research on the matter was carried out by Salk Institute in California researchers. They were led by Juan Carlos Izpisua Belmonte. He is a doctor and Salk Gene Expression Laboratory professor.
Research results were published last week. On December 15, they were released in the Cell journal.
Belmonte also went to release a statement. According to him, aging might become reversible through careful modulation. The doctor stated that aging may come to proceed in more than one direction.
His team’s studies attested to the theory. Research found that at least some aging effects could become reversible.
The team has been carrying out mice trials. Their study targeted a specific cells group. Such a potentially reversible aging cell group has been known to scientists.
It is comprised of four genes. They are collectively called the Yamanaka factors. Their name is based on the discoveries of Shinya Yamanaka’s lab. Such Japanese research pioneered induced pluripotent stem cells techniques.
The reversible aging cell group has also raised questions. Its potential rejuvenating effects have been acknowledged. However, tinkering with the Yamanaka factors may also have unwished-for consequences.
The technique is based on the reversal of adult cells to a stem cell status. Scientists fear that by doing so, they may damage organs. They also fear the potential appearance of certain diseases. More specifically, cancer.
Belmonte and his team studied the four cell groups. Research showed that during womb development, they were particularly active.
Their study also studied laboratory human skin cells. These were found to have been rejuvenated after applying the technique. This stimulates the respective reversible aging cell group.
As the human skin cells looked younger, they also behaved as such. Most trials were carried out on mice. The involved scientists acknowledged the fact that a human rejuvenation process would be more complex.
However, they also pointed out a specific fact. Belmonte stated that their research revealed an aging property. More exactly, its more plastic and dynamic processes.
As such, they consider that therapeutic interventions could be more amenable.
The Salk team of researchers used a different stimulating technique. They proceeded to stimulate the genes intermittently.
By doing so, they reportedly did not face any damaging side effects. Their trials saw two types of mice. One presented a premature aging disease.
In such cases, the technique was seen to counter aging signs. It also marked a 30 percent increase in their lifespan.
The stimulation technique was also applied to healthy mice. Besides the said effects, they also presented an added treatment. Potentially damaged organs were seen to have healed faster.
If such a technique would become safe to use on humans, its advantages would be considerable. It could potentially increase the average lifespan to more than 100 years. It would potentially also ensure a healthier life.
Such an effect would be ensured by the delayed appearance of age-related diseases. As the global population is aging, researchers are expecting an increased number of such health issue.
Age-related diseases include heart problems or dementia cases.
Further studies would have to be made before testing the new theory. Its effects and potential human efficiency remain to be determined.
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